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原文件 普通视图 历史 永久链接
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<!DOCTYPE html>
<html lang="en">
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<head>
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    <meta charset="UTF-8" />
    <meta name="viewport" content="width=device-width, initial-scale=1, maximum-scale=1, user-scalable=no" />
    <meta http-equiv="X-UA-Compatible" content="ie=edge" />
    <link rel="stylesheet" href="../css/bootstrap.min.css" />
    <link rel="stylesheet" href="../css/swiper-3.4.2.min.css" />
    <link rel="stylesheet" href="../css/base.css" />
    <link rel="stylesheet" href="../css/index.css" />
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    <title>Tianjin Medical University Cancer Institute & Hospital</title>
    <style>
        .single_box {
            width: 600px;
            margin-bottom: 44px;
        }
        
        .single_box:last-child {
            margin: 0;
        }
        
        .content-word {
            position: relative;
        }
        
        .content-word-left {
            width: 300px;
            flex: unset;
            align-self: flex-start;
            justify-self: flex-end;
            margin-left: 60px;
        }
        
        .content-word-right {
            flex: 1;
            display: none !important;
            display: -webkit-flex;
            flex-wrap: wrap;
            padding: 0;
            position: relative;
        }
        
        .content-word-right.active {
            display: flex !important;
        }
        
        .content-word-right .single_part {
            width: 243px;
            display: flex;
            margin-bottom: 50px;
            font-size: 17px;
            color: #040404;
            flex-flow: column;
            align-items: flex-start;
            margin-left: 50px;
        }
        
        .content-word-left h4 {
            color: #232323;
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            opacity: 0.7;
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            line-height: 2.5;
            padding: 0;
            margin: 0;
            cursor: pointer;
        }
        
        .single_part p {
            margin-top: 10px;
        }
        
        .content-word-left {
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            background: #ebfbf8;
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            height: 863px;
            position: relative;
        }
        
        .part_box {
            width: 242px;
            height: 115px;
            overflow: hidden;
            background-color: #898989;
        }
        
        .depart_introduce {
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            background: #ebfbf8;
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            overflow: hidden;
            color: #232323;
            margin-top: 60px;
            box-sizing: border-box;
            padding: 20px;
            padding-bottom: 50px;
            width: 100%;
        }
        
        .depart_introduce.auto {
            height: auto;
        }
        
        .part_top {
            height: 74px;
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            background: #83ad9f;
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            color: #000000;
            font-size: 16px;
            font-weight: bold;
            text-align: center;
            line-height: 74px;
        }
        
        .part_inner_content {
            padding: 20px 40px;
        }
        
        .person_introduce_box {
            border-top: 5px solid #999;
            margin-top: 100px;
            padding-top: 50px;
        }
        
        .person_introduce_box h3 {
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            color: #00a16c;
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        }
        
        .next {
            width: 32px;
            height: 22px;
            position: absolute;
            bottom: -15px;
            left: 50%;
            margin-left: -11px;
            cursor: pointer;
        }
        
        .contant {
            width: 1122px;
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            margin: 12px auto 0 auto;
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        }
        
        .contant_top_img {
            width: 256px;
        }
        
        .contant_top_img img {
            width: 100%;
        }
        
        .contant_top_word {
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            margin-top: 32px;
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        }
        
        .contant_name {
            font-size: 30px;
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            font-weight: bold;
            color: #727171;
            line-height: 24px;
            margin-bottom: 20px;
        }
        
        .contant_names {
            font-size: 30px;
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            font-weight: 400;
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            color: #727171;
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            line-height: 24px;
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            margin-bottom: 20px;
        }
        
        .contant_title {
            margin-top: 36px;
            font-size: 20px;
            font-weight: bold;
            color: #727171;
        }
        
        .contant_words {
            text-align: justify;
            font-size: 20px;
            font-weight: 400;
            line-height: 30px;
            color: #727171;
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        }
        
        .contant_center {
            margin-top: 30px;
            font-size: 20px;
            color: #565656;
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            line-height: 30px;
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        }
        
        .contant_center h3 {
            font-size: 20px;
            line-height: 30px;
            color: #565656;
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            font-weight: bold;
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        }
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        .contant_bottom {
            margin-top: 36px;
        }
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        .contant_words span {
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            color: #008dd7;
            border-bottom: 1px solid #008dd7;
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        }
    </style>
</head>
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<body>
    <nav class="navbar navbar-default bgf mb0">
        <div class="container-fluid top_pc_brand">
            <div class="navbar-header">
                <button type="button" class="navbar-toggle mtperc10 menuPage" data-toggle="collapse" data-target="#bs-example-navbar-collapse-4" aria-expanded="true">
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            <span class="sr-only">Toggle navigation</span>
            <span class="icon-bar"></span>
            <span class="icon-bar"></span>
            <span class="icon-bar"></span>
          </button>
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                <a class="navbar-brand logo" href="../index.html">
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                    <img class="brand-logo" src="../images/logo.png" alt="" />
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                </a>
            </div>
            <div class="navbar-collapse collapse in" id="bs-example-navbar-collapse-4" aria-expanded="true">
                <div class="search-group mt30 form-group navbar-text navbar-right">
                    <a href="http://www.tjmuch.com/" class="langue">中文</a>
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                    <input type="text" class="form-control search-input" placeholder="Search" />
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                    <div class="magnifier">
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                        <img src="../images/01pc-main/pic%20(11).png" alt="" />
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                    </div>
                </div>
            </div>
        </div>
    </nav>
    <div class="container-fluid pc">
        <div class="mask"></div>
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        <div class="bs-example" data-example-id="simple-justified-button-group">
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            <ul class="nav_menu_items">
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                <li class="btn  navbtnActive navbtn-a" role="button">
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                    <a href="javascript:;">ABOUT US</a>
                    <div class='sec_menu_items'>
                        <a href="../about/welcome.html" class="inner_item">
                            Welcome Message
                        </a>
                        <a href="../about/mission.html" class="inner_item">
                            Mission and Vision
                        </a>
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                        <!-- <a href="../about/leadership.html" class="inner_item">
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                            Leadership
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                        </a> -->
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                        <a href="../about/history.html" class="inner_item">
                            History and Milestones
                        </a>
                        <a href="../about/quick.html" class="inner_item">
                            Quick Facts
                        </a>
                        <a href="../about/contact.html" class="inner_item">Contact Us</a>
                    </div>
                </li>
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                <li class="btn  navbtn-a" role="button">
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                    <a href="JavaScript:;">CLINICAL RESOURCES</a>
                    <div class='sec_menu_items'>
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                        <div class="inner_item">
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                            Clinical Departments
                            <div class="third_menu_items">
                                <a href="../clinical/departm.html" class="inner_item">
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                                    Surgical Oncology
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                                </a>
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                                <a href="../clinical/medical.html" class="inner_item">
                                    Medical Oncology
                                </a>
                                <a href="../clinical/radiation.html" class="inner_item">
                                </a>
                                <a href="../clinical/diagnostic.html" class="inner_item">
                                    Diagnostic Oncology
                                </a>
                                <a href="../clinical/center.html" class="inner_item">
                                    Center of Excellences
                                </a>
                            </div>
                        </div>
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                        <a href="../clinical/activities.html" class="inner_item">
                            Clinical Activities
                        </a>
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                        <div class="inner_item">
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                            Clinical Trials
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                            <div class="third_menu_items">
                                <a href="../clinical/trials.html" class="inner_item">
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                                    Introduction
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                                </a>
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                                <a href="../clinical/trials_one.html" class="inner_item">
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                                    Work Flow Chart
                                </a>
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                                <a href="../clinical/trials_two.html" class="inner_item">
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                                    FInd A Clinical Trail
                                </a>
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                                <a href="../clinical/trials_three.html" class="inner_item">
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                                    Research Achievement
                                </a>
                            </div>
                        </div>
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                        <a href="../clinical/finddoctor.html" class="inner_item">
                            Find a Doctor
                        </a>
                    </div>
                </li>
                <li class="btn  navbtn-a" role="button">
                    <a href="javascript:;">RESEARCH & EDUCATION</a>
                    <div class='sec_menu_items'>

                        <a href="../research/nationalCancer.html" class="inner_item">
                            National Cancer Clinical Research Center
                        </a>
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                        <div class="inner_item">
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                            Research
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                                <a href="../research/research1.html" class="inner_item">
                                    Research programs
                                </a>
                                <a href="../research/research2.html" class="inner_item">
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                                    Achievements
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                                </a>
                                <a href="../research/research3.html" class="inner_item">
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                                    Key Labaratories
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                                </a>
                                <a href="../research/researcher.html" class="inner_item">
                                    Find a Researcher
                                </a>
                            </div>
                        </div>
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                        <div class="inner_item">
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                            Education
                            <div class="third_menu_items">
                                <a href="../research/education.html" class="inner_item">
                                    Graduate Study
                                </a>
                                <a href="../research/education.html" class="inner_item">
                                    International Study
                                </a>
                                <a href="../research/education.html" class="inner_item">
                                    Continuing Study
                                </a>
                            </div>
                        </div>
                    </div>
                </li>
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                <li class="btn  navbtn-a" role="button">
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                    <a href="javascript:;">TIANJIN CANCER INSTITUTE</a>
                    <div class='sec_menu_items'>
                        <div href="javascript:;" class="inner_item">
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                            Abouts Us
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                            <div class="third_menu_items">
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                                <a href="../institute/aboutus.html" class="inner_item">
                                    Introduction
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                                </a>
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                                <a href="../institute/leadership.html" class="inner_item">
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                                    Leadership
                                </a>
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                                <a href="../institute/history.html" class="inner_item">
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                                    History
                                </a>
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                                <a href="../institute/report.html" class="inner_item">
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                                    Annual Report
                                </a>
                            </div>
                        </div>
                        <div href="../clinical/nursing.html" class="inner_item">
                            Research
                            <div class="third_menu_items">
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                                <a href="../institute/researchers.html" class="inner_item">
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                                    Our Researchers
                                </a>
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                                <a href="../institute/facilities.html" class="inner_item">
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                                    Core Facilities and Services
                                </a>
                                <a href="http://www.cancerbiomed.org/index.php/cocr" class="inner_item">
                                    Journal of Clinical Oncology
                                </a>
                            </div>
                        </div>
                    </div>
                </li>
                <li class="btn  navbtn-a" role="button">
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                    <a href="javascript:;">NURSING CARE</a>
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                    <div class='sec_menu_items'>
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                        <div class="inner_item" style="position: relative">
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                            Introduction
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                            <div class="third_menu_items">
                                <a href="../care/history_time.html" class="inner_item">
                                  Our Team
                                </a>
                                <a href="../care/history_time_two.html" class=" inner_item ">
                                   Imoportant Events
                                </a>
                                <a href="../care/history_time_three.html " class="inner_item ">
                                 Honor & Awards
                                </a>
                                <a href="../care/history_time_four.html " class="inner_item ">
                                   Contact Us
                                </a>
                            </div>
                        </div>
                        <div class="inner_item " style="position: relative ">
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                            Nursing Activities
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                            <div class="third_menu_items ">
                                <a href="../care/profession.html " class="inner_item ">
                                  Professional Teams
                                </a>
                                <a href="../care/five-two_2.html" class="inner_item ">
                                   Public Services
                                </a>
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                                <a href="../care/profession_one.html" class="inner_item ">
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                                 Compassionate Care
                                </a>
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                                <a href="../care/profession_two.html" class="inner_item ">
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                                   Caring for Nurses
                                </a>
                            </div>
                        </div>
                        <div class="inner_item " style="position: relative ">
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                            Nursing Teaching
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                            <div class="third_menu_items ">
                                <a href="../care/training.1.html" class="inner_item ">
                                 Clinical Nursing Teaching
                                </a>
                                <a href="../care/five-three_2.html" class="inner_item ">
                                  Postgraduate Development
                                </a>
                            </div>
                        </div>
                        <div class="inner_item ">
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                            Nursing Research
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                            <div class="third_menu_items ">
                                <a href="../care/five-four_detail1.html " class="inner_item ">
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                                  Publications:SCI Papers
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                                </a>
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                                <a href="../care/five-four_detail2.html" class="inner_item ">
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                                   Research Projects
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                                </a>
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                                <a href="../care/five-four_detail3.html" class="inner_item ">
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                                 Innovations & Patents
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                                </a>
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                                <a href="../care/five-four_detail4.html " class="inner_item ">
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                                   Publications:Books
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                                </a>
                            </div>
                        </div>
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                        <a href="../care/cancer.html " class="inner_item ">
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                            Survivorship Support
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                        </a>
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                    </div>
                </li>
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                <li class="btn navbtn-a " role="button ">
                    <a href="javascript:; ">INTERNATIONAL AFFAIRS</a>
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                    <div class='sec_menu_items'>
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                        <a href="../international/conference.html " class="inner_item ">
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                            International Conferences
                        </a>
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                        <a href="../international/training.html " class="inner_item ">
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                            Oversea Trainings
                        </a>
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                        <a href="../international/referral.html " class="inner_item ">
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                            International Patients
                        </a>
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                        <a href="../international/partners.html " class="inner_item ">
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                            Partnership Institutions
                        </a>
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                Tianjin Cancer Institute<span>></span>Research<span>></span>Our Researchers
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                        <img src="../images/lixiangchun.png" alt="" />
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                            Prof. Xiangchun Li
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                        <div class="contant_names">
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                            Professor of Department of Public Laboratory
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                <div class="contant_word">
                    <div class="contant_title">Education:</div>
                    <div class="contant_words">
                        2006.9-2010.7 Bachelor of Engineering in Bioinformation Technology, Huazhong University of Science and Technology,
                    </div>
                    <div class="contant_words">
                        2012.8~2016.12 Ph.D in Medical Sciences, Chinese University of Hong Kong,
                    </div>
                    <div class="contant_title">Professional Experiences:</div>
                    <div class="contant_words">
                        2010.7~2012.8 NGS data analyst, Beijing Genomics Institute, Shenzhen,
                    </div>
                    <div class="contant_words">
                        2017.2~present Professor, Tianjin Cancer Institute, Tianjin Medical University Cancer Institute and Hospital,
                    </div>
                    <div class="contant_title">
                        Research Focus
                    </div>
                    <div class="contant_words">
                        Our research focuses on characterizing mutational landscape of human gastrointestinal cancer, elucidating the association between mutational footprints and environmental factors, identifying biomarkers with translational significance in immunotherapy
                        and early cancer diagnosis, and interpreting medical imaging data using deep learning algorithms. Through bioinformatics analyses, we identified new driver genes underlying the development of gastrointestinal cancer, and shed new
                        lights on genetic markers that are potentially clinically actionable. By applying deep learning algorithm to analyze large-scale sonographic imaging data, we developed a deep learning model that could augment radiologists’ ability
                        in thyroid cancer diagnosis. We have published more than 20 peer-reviewed articles in international journals, including Lancet Oncology, JAMA Oncology, and Annals of Oncology etc.
                    </div>
                    <div class="contant_title">Selected Publications</div>
                    <div class="contant_words">
                        1. Li X#, Zhang S#, Zhang Q#, Wei X#, Pan Y, Zhao J, Xin X, Qin C, Wang X, Li J, Yang F, Zhao Y, Yang M, Wang Q, Zheng Z, Zheng X, Yang X, Whitlow CT, Gurcan MN, Zhang L, Wang X, Pasche BC, Gao M, Zhang W*, Chen K*. Diagnosis of thyroid cancer using deep
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wangyi authored
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                        convolutional neural network models applied to sonographic images: a retrospective, multicohort, diagnostic study. Lancet Oncol. 2019 Feb;20(2):193-201. <span>doi: 10.1016/S1470-2045(18)30762-9.</span> Epub
                        2018 Dec 21.
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                        2. Li X#, Pasche B, Zhang W*, Chen K*. Association of MUC16 Mutation With Tumor Mutation Load and Outcomes in Patients With Gastric Cancer. JAMA Oncol. 2018 Dec 1;4(12):1691-1698. <span>doi: 10.1001/jamaoncol.2018.2805.</span>                        PubMed PMID: 30098163.
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                    </div>
                    <div class="contant_words">
                        3. Li X#, Wang MY, Yang M, Dai HJ, Zhang BF, Wang W, Chu XL, Wang X, Zheng H, Niu RF, Zhang W*, Chen KX*. A mutational signature associated with alcohol consumption and prognostically significantly mutated driver genes in esophageal squamous cell carcinoma.
                        Ann Oncol. 2018 Apr 1;29(4):938-944. <span>doi: 10.1093/annonc/mdy011.</span> PubMed PMID: 29351612; PubMed Central PMCID: PMC5913594.
                    </div>
                    <div class="contant_words">
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wangyi authored
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                        4. Chen K#, Yang D#, Li X#, Sun B, Song F, Cao W, Brat DJ, Gao Z, Li H, Liang H, Zhao Y, Zheng H, Li M, Buckner J, Patterson SD, Ye X, Reinhard C, Bhathena A, Joshi D, Mischel PS, Croce CM, Wang YM, Raghavakaimal S, Li H, Lu X, Pan Y, Chang H, Ba S, Luo
                        L, Cavenee WK*, Zhang W*, Hao X*. Mutational landscape of gastric adenocarcinoma in Chinese: implications for prognosis and therapy. Proc Natl Acad Sci U S A. 2015 Jan 27;112(4):1107-12. <span>doi: 10.1073/pnas.1422640112.</span>                        Epub 2015 Jan 12. PubMed PMID: 25583476; PubMed Central PMCID: PMC4313862.
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                    </div>
                    <div class="contant_words">
                        5. Song Y#, Li L#, Ou Y#, Gao Z#, Li E#, Li X#, Zhang W, Wang J, Xu L, Zhou Y, Ma X, Liu L, Zhao Z, Huang X, Fan J, Dong L, Chen G, Ma L, Yang J, Chen L, He M, Li M, Zhuang X, Huang K, Qiu K, Yin G, Guo G, Feng Q, Chen P, Wu Z, Wu J, Ma L, Zhao J, Luo
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wangyi authored
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                        L, Fu M, Xu B, Chen B, Li Y, Tong T, Wang M, Liu Z, Lin D, Zhang X, Yang H, Wang J, Zhan Q*. Identification of genomic alterations in oesophageal squamous cell cancer. Nature. 2014 May 1;509(7498):91-5. <span>doi: 10.1038/nature13176.</span>                        Epub 2014 Mar 16. PubMed PMID: 24670651.
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544 545 546 547 548 549 550 551 552 553 554 555 556 557 558 559 560 561 562 563 
                    </div>
                    <div class="contant_words">
                        6. Wang X#, Li X#, Zhang L#, Wong SH, Wang MHT, Tse G, Dai RZW, Nakatsu G, Coker OO, Chen Z, Ko H, Chan JYK, Liu T, Cheng CHK, Cheng ASL, To KF, Plewczynski D, Sung JJY, Yu J, Gin T*, Chan MTV*, Wu WKK*. Oncogenes expand during evolution to withstand
                        somatic amplification. Ann Oncol. 2018 Nov 1;29(11):2254-2260. <span>doi: 10.1093/annonc/mdy397.</span> PubMed PMID: 30204835.
                    </div>
                    <div class="contant_words">
                        7. Li X#, Xu W#, Kang W, Wong SH, Wang M, Zhou Y, Fang X, Zhang X, Yang H, Wong CH, To KF, Chan SL, Chan MTV, Sung JJY, Wu WKK*, Yu J*. Genomic analysis of liver cancer unveils novel driver genes and distinct prognostic features. Theranostics. 2018;8(6):1740-1751.
                        <span>doi: 10.7150/thno.22010.</span> eCollection 2018. PubMed PMID: 29556353; PubMed Central PMCID: PMC5858179.
                    </div>
                    <div class="contant_words">
                        8. Li X#, Wu WK*, Xing R, Wong SH, Liu Y, Fang X, Zhang Y, Wang M, Wang J, Li L, Zhou Y, Tang S, Peng S, Qiu K, Chen L, Chen K, Yang H, Zhang W, Chan MT, Lu Y, Sung JJ, Yu J*. Distinct Subtypes of Gastric Cancer Defined by Molecular Characterization Include
                        Novel Mutational Signatures with Prognostic Capability. Cancer Res. 2016 Apr 1;76(7):1724-32. <span>doi: 10.1158/0008-5472.CAN-15-2443.</span> Epub 2016 Feb 8. PubMed PMID: 26857262.
                    </div>
                    <div class="contant_words">
                        9. Nakatsu G#, Li X#, Zhou H#, Sheng J#, Wong SH#, Wu WK#, Ng SC, Tsoi H, Dong Y, Zhang N, He Y, Kang Q, Cao L, Wang K, Zhang J, Liang Q, Yu J*, Sung JJ*. Gut mucosal microbiome across stages of colorectal carcinogenesis. Nat Commun. 2015 Oct 30;6:8727.
                        <span>doi: 10.1038/ncomms9727.</span> PubMed PMID: 26515465; PubMed Central PMCID: PMC4640069.
                    </div>
                    <div class="contant_words">
                        10. Yu J#*, Wu WK# Li X#, He J, Li XX, Ng SS, Yu C, Gao Z, Yang J, Li M, Wang Q, Liang Q, Pan Y, Tong JH, To KF, Wong N, Zhang N, Chen J, Lu Y, Lai PB, Chan FK, Li Y, Kung HF, Yang H, Wang J*, Sung JJ*. Novel recurrently mutated genes and a prognostic
                        mutation signature in colorectal cancer. Gut. 2015 Apr; 64(4): 636-45. <span>doi: 10.1136/gutjnl-2013-306620.</span> Epub 2014 Jun 20. PubMed PMID: 24951259; PubMed Central PMCID: PMC4392212.
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