作者 王毅

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Clinical Resources<span>></span>Clinical Departments
<span>></span>Surgical Oncology<span>></span>Gastric Surgery Department
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The Department of Gastric Surgery of Tianjin Medical University Cancer Institute and Hospital, whose predecessor was the Department of Abdominal Surgical Oncology founded by the late distinguished tumor expert, Professor Jin Xianzhai in 1972, was established
as an independent department and renamed as such in 2004 as a result of disciplinary specialization. The department, with 69 assigned beds and a faculty of 17 doctors, including 6 attendings, 6 fellows and 5 residents, of whom
90% are medical doctoral degree holders, provides surgical treatments of a wide range of gastric diseases such as gastric cancer, gastrointestinal stromal tumors (GISTs), peritoneal neoplasm and retroperitoneal neoplasm etc.
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<div class="contant_words">
The department, composed of a team of first-class surgeons specializing in gastro-intestinal tumors, is renowned for its clinical expertise and excellent surgical techniques and enjoys a fine reputation both home and abroad, therefore attracting numerous
patients from Tianjin and other provinces. The quantity and quality of operations performed by the department has been rising continually every year. In 2018, the number of outpatients reached 21624 and that of discharged patients,
3283; meanwhile 1015 operations were performed and 84.15% of them were on gastric cancer patients. The surgical treatment of gastric cancer of our department attaches importance to standard D2 radical resection with standard lymph
node dissection, which not only increases greatly the survival rate but also promotes the accuracy of pathological stage of gastric cancer, hence provides better prognosis and suitable comprehensive therapeutic plans after the
surgery. Therefore, our department has been taking a leading role in gastric cancer treatment and its prognosis and participating in setting the criteria of standardized gastric cancer treatment. The department has a unique advantage
in the field of digestive tract reconstruction. It adopts the standard B-I, B-II, Roux-en-Y and explores new means of rebuilding the digestive tract as well. In 2011, our department undertook a major national research project,
“A Clinical Study into the Effect of Different Means of Reconstructing Digestive Tract on Improving the Patients’ Life Quality After the Surgeries of Total Gastrectomy”, which compares Roux-en-Y and functional jejunal interposition
(FJI) and their effects on long-term postoperative complications and life quality of the patients who have received such surgeries. For gastric cancer patients of early stages, we advocate minimally invasive (laparoscopic and Da
Vinci) surgery in order to reduce perioperative complications, and have achieved favorable results; for patients of advanced stages, neoadjuvant chemotherapies are adopted to improve the surgical resection and 5-year survival rates.
For patients with peritoneal metastasis or the risk of tumor peritoneal dissemination, peritoneal thermal perfusion chemotherapies have been carried out earlier than other institutions in China to prevent and treat the peritoneal
spread of advanced gastric cancer, and have achieved satisfactory results. In the treatment of patients with gastrointestinal stromal tumor, the advantages of the combined treatment of operation and postoperative targeted drugs
are emphasized, and patients are encouraged to have regular postoperative review to find the drug resistance timely, and adjust the treatment plan in time to obtain satisfactory treatment effect. Specializing in gastric cancer
and the relevant expertise, we are also capable of performing difficult and complicated surgeries with satisfactory results.
</div>
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In recent years, our department has made it a regular practice to hold the Multiple Disciplinary Team (MDT) symposium, which invites experts from departments of surgery, pathology, oncology, radiology etc., to meet bi-weekly on Thursday and join in discussions
about patients’ diseases and their conditions so that the most pertinent treatment strategies can be adopted according to each individual patient’s medical condition and therefore it can ensure that every gastric cancer patient
receives the best individualized treatment possible.
</div>
<div class="contant_words">
Besides the surgeries and other clinical work, the Department of Gastric Surgery has also been engaged in clinical and fundamental research related to gastric cancer. We have established long-term collaboration with Massachusetts General Hospital of Harvard
University, and Cancer Institute Hospital of JFCR, Seoul National University Hospital, Yonsei University of Korea and Institute of Digestive Disease of The Chinese University of Hong Kong. Meanwhile, our department has undertaken
research projects of various levels, including 1 National 973 Project, 1 National Natural Sciences Project, 3 provincial research projects, 1 key Tianjin anti-cancer research project, 4 institutional projects and 7 hospital projects.
In addition, 221 research papers completed by our department have been published, among which 104 are in SCI journals, 93 in Chinese Medical Journal Series, 24 in key Chinese journals, with the impact factor reaching 18.38 at its
best. In 2018, 361 cases were involved in various clinical researches, accounting for 31.6% of all surgeries. Our department graduates 3-4 students with master’s degree annually and so far has graduated more than 40 students in
total. Besides, our department hosts the interns of Tianjin Medical University and offers training and teaching to the 7-year students of Tianjin Medical University as well as the surgeons from other provinces for further learning.
Moreover, we have participated in writing, compiling and translating a dozen of monographs including Gastric Cancer, Visual Lectures on Operation for Gastric Cancer, Principles and Practice of Gastrointestinal Oncology, Basic Clinical
Surgery, Abdominal Oncology, Surgical Oncology, Oncology, Concise Oncology, all of which have been published, and among which, Visual Lectures on Operation for Gastric Cancer has been included in a series of academic monographs
on the 30th anniversary of the Chinese anti-cancer association.
</div>
<div class="contant_words">
Our department has been involved actively in academic exchanges with peers from both China and other countries. Sino-Japan-Korea Gastric Cancer Submit hosted by our department has become a well-known brand conference on gastric cancer and the clinical
work and research results have been recognized and applauded both domestically and internationally.
</div>
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<div class="contant_bottom_title">Our Team</div>
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<div class="contant_bottom_name">Han Liang,MD</div>
<div class="contant_bottom_label">Director, Professor</div>
</div>
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system. After 3 years of hard work, our department was accredited to ISO 15189 in 2013 and
become the first ISO credited lab among the five affiliated hospitals of Tianjin Medical
University. Working with accreditation of ISO15189 will enable us to meet international
standards for patient care and laboratory management. The testing reports issued by our
department are accepted by more than 50 countries and regions all around the world. Our goal is
to be persist in pursuing high quality lab test results.
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Clinical Resources<span>></span>Clinical Departments
<span>></span>Surgical Oncology<span>></span>Gastric Surgery Department
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Professor Han Liang is a well-known domestic gastric cancer surgery specialist, and he engaged in gastric cancer surgery and comprehensive treatment for more than 33 years. His professional interest includes peritoneal sustained release chemotherapy and
intraperitoneal hyperthermia peritoneal chemotherapy (HIPEC) for locally advanced gastric cancer and they were carried out earlier in China. He has long devoted himself to the clinical study of radical gastrectomy and the regularity
of lymph node metastasis in gastric cancer. Another interested field is clinical and experimental study on digestive tract reconstruction after gastrectomy. As a core member of the Expert Group, he participated in the national
tour and training of standard surgery for gastric cancer for more than 10 years. Participate in the important clinical research of gastric cancer in China. Presided over more than 10 national and provincial scientific research
projects, published 300 scientific research papers and articles, including more than 100 SCI papers. As editor-in-chief, publish two books about gastric cancer and as the deputy editor-in-chief, the publish another 2 monographs.
As a main translation, publish two translations 2. Served as the editorial board of many academic journals, as the Chairman-designate of the Professional Committee on Gastric Cancer of China Anticancer Association. The level of
comprehensive treatment of gastric cancer surgery and gastric surgery in Tianjin Cancer Hospital is the leading level in China.
</div>
<div class="contant_one">
<div class="contant_one_title">Education & Training</div>
<div class="contant_words">
• German Language Institute, Beijing Foreign Language University, 1991-1992
</div>
<div class="contant_words">
• Guest Doctor, Department of General Surgery, State Hospital St. Gallen, Switzerland, 1992-1994
</div>
<div class="contant_words">
• Visiting Fellow, MDC Molecular Medical Center, Roberet-roessle Clinic, Charte, Humboldt University of Berlin, Germany, 1999-2000
</div>
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• Visiting Fellow, MD Anderson Cancer Center, Huston, Texas, USA, 2007
</div>
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• MD, Medical Faculty, Tianjin Medical College, Tianjin 1980-1985
</div>
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<div class="contant_one_title">Current Positions</div>
<div class="contant_words">
• Director of Gastrointestinal Oncological Surgery, Tianjin Medical University Cancer Institute and Hospital, Tianjin, China. Chief Doctor, Professor of Tianjin Medical University. 2004.
</div>
</div>
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<div class="contant_one_title">
Previous Professional Experiences
</div>
<div class="contant_words">
• Director of Gastric Cancer Surgical Department, Tianjin Medical University Cancer Institute & Hospital, 2004-2016
</div>
<div class="contant_words">
• Deputy Director of Gastrointestinal Oncological Surgery, Tianjin Medical University Cancer Institute and Hospital, Chief Doctor, 2000-2004.
</div>
<div class="contant_words">
• Deputy-Chief Doctor, Department of Abdominal Oncology, Tianjin Medical University Cancer Institute and Hospital, 1995-2000.
</div>
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• Resident, Department of Abdominal Oncology, Tianjin Cancer Hospital, 1985-1995
</div>
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Board Certification
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• Members of Board, Chinese Anti-Cancer Association, 1997,
</div>
<div class="contant_words">
• Members of Chinese Medical Association, 1990,
</div>
<div class="contant_words">
• Vice-President of Gastric Committee, Chinese Anti-Cancer Association, 2010,
</div>
<div class="contant_words">
• Vice-President of Gastric Cancer Committee, Chinese Medical Association,2013
</div>
<div class="contant_words">
• Vice-President of Surgical Oncologic Committee, Chinese Doctor’s Association,2014
</div>
<div class="contant_words">
• Member of International Gastric Association
</div>
</div>
<div class="contant_one">
<div class="contant_one_title">
Recent key publications (2014-present)
</div>
<div class="contant_words">
1. Deng JY,Zhang RP, Pan Y, Wang BG, Wu LL, Jiao XG, Bao T, Hao XS, Liang H. Comparison of the staging of regional lymph nodes using the sixth and seventh editions of the TNM classification system for the evaluation of overall survival in gastric cancer
patients: findings of a case-control analysis involving a single institute in China. Surgery 2014;156(1):64-74
</div>
<div class="contant_words">
2. Deng JY, Zhang RP, Liang H, et al. Methylated CpG site count of dapper homolg 1 (DACT1) promoter prediction the poor survival of gastric cancer. Am J Cancer Res 2014;4(5):518-27
</div>
<div class="contant_words">
3. Deng JY, zhang R, Jiang N, Liang H, et al. Superior of the ratio between negative and positive LN for predicting the prognosis for patients with GC. Ann Surg Oncol 2014;DOI 10.1245/s10434-014-4128-8
</div>
<div class="contant_words">
4. Deng JY, Jiang N, Liu Hong G, Liang H. Clinical significance of the methylated cytosine-phosphate- guanine sites of protocadherin-10 promoter for evaluating the prognosis of gastric cancer. J Am Coll Surg 2014 Jun 26. Pii: S1072-7515(14)00502-X
</div>
<div class="contant_words">
5. Deng JY, Zhang RP, Pan Y, Ding XW, Cai MZ, Liu Y, Liu HG, Bao T, Jiao XG, Hao XS, Liang H. Tumor size as a recommendable variable for accuracy of the prognostic prediction of gastric cancer: a retrospective analysis of 1521 patients. Ann Surg Oncol
2014;Aug 26, doi:10.1245/s10434-014-4014-x
</div>
<div class="contant_words">
6. Deng JY, Liu H, Liang Y, Liang H, et al. Methylation of ras association domin protein 10 promoter negative association with the survival of gastric cancer. Am J Cancer Res2014;4(6):916-23
</div>
<div class="contant_words">
7. Jiang N, Deng JY, Liang H, et al. Node-extranodal soft tissue stage based on extranodal metastasis is associated with poor prognosis of patients with gastric cancer. J Surg Res 2014;192(1):90-7
</div>
<div class="contant_words">
8. Jiao XG, Deng JY, Wang XN, Liang H. Prognostic value of number of examined lymph nodes in patients with node-negative gastric cancer. J Gastroenterol. 2014 Apr 7;20(13):3640-8.
</div>
<div class="contant_words">
9. Liang Y, Deng JY, Liang H, et al. The opsitive impact of surgeon superiorlization on survival for gastric cancer patients with curative intent. Gastric Cancer. 2014 Oct 15. [Epub ahead of print]PMID:25315086
</div>
<div class="contant_words">
10. Jiang N. Deng J, Liang H, et al. Tumor volume as a prognostic factor was superior to the seventh edition of the pT classification in resectable gastric cancer. Eur J Surg Oncol. 2015;41(3):315-22.
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Wang Donghao
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3. Wang YN, Yao S, Wang CL, Li MS, Sun LN, Yan QN, Tang SW, Zhang ZF. Clinical Significance of 4L Lymph Node Dissection in Left Lung Cancer. J Clin Oncol. 2018 Oct 10;36(29):2935-2942. (IF 26.303)
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International Oncology Nursing Summit Forum-2012 Tianjin
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2015 Nobel Prize Laureate Summit on Biomedical Sciences:Frontiers in Cancer Research
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International Affairs<span>&gt;</span>International Affairs
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Sino-German Round Table Symposium on Cancer Precision Medicine in the Era of Big Data: Tianjin 2019
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The “Sino-German Round Table Symposium on Cancer Precision Medicine in the Era of Big Data”, was successfully held by Tianjin Medical University Cancer Institute & Hospital (TMUCIH) and German Cancer Research Center (DKFZ) on June 19-20, 2019 in Tianjin.
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This symposium created a collaborative forum for interactive discussions and thought-provoking exchanges on cancer precision medicine, and brought together leading scientists and scholars from both institutions to give highlighted presentations, with
the aim of promoting sustainable scientific research collaborations between China and Germany. <br />The symposium‘s academic exchange was rich and fruitful involving both basic and clinical research on neuro-oncology,
pancreatic cancer, immunology, data integration, artificial intelligence, genomics, pediatric cancer, radiation oncology, lung cancer, gastrointestinal oncologyand immuno-oncology. It demonstrated outstanding achievements in the merging
of different fields and the novel methods of diagnosis and treatment. <br />This symposium also provided an unique oppotunity for learning, sharing and exchanging the latest achievement and working experiences among clinicians, researchers
and students. All the participants have benifited significantly from the in-depth discussion on cancer precision medicine.<br />TMUCIH and DKFZ are among the largest comprehensive cancer centers in China and Germany. The two institutions
signed a MOU in November, 2018, aming to establish solid scientific research collaboration and to strive for breakthrough research results in cancer precision medicine by combining the strengths and resources from both sides. We are
pleased to see that our exchange and cooperation is developing further through our collaborative efforts. We are looking forward to working together with DKFZ to pave the way for generating fruitful collaborations in the future. We
anticipate reaching many milestones together.
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Research & Education<span>></span>National Cancer Clinical Research Center
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National Clinical Research Center for Cancer (China • Tianjin)
National Clinical Research Center for Cancer ( Tianjin, China)
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In 2012, the Ministry of Science and Technology, together with the Ministry of Health and the Ministry of General Health started up the construction of National Clinical Research Center, which was divided into three batches to build total of 32 centers.
In June 2013, our center was established at the first batch, while was one of the two National Clinical Research Centers in the field of cancer.
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Since the Center’s inception, we see the center as the guide and the collaborative network as the support. We aim to make the establishment of a high-level research platform for the oncology-transforming medicine.
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In additions, we work on launching the clinical and translational studies, exploring the new model and new technology of the cancer prevention & treatment, and popularizing the diagnostic and therapeutic criteria for the common malignant tumors. By facing
the needs of the cancer prevention & treatment, the Center has cultivated the multidisciplinary research teams, and strengthened the technological promotion and popularization.
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Academician Xishan Hao is the director of the Center,who established the organizational and management structure of the Center. The Center has been formed collaborative research network within two sub-centers, 20 regional centers and several grass-roots
hospitals.
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Research Platform Construction: the Center established the specifications for the construction and management of biological samples in accordance with international standards and formed the internationalized Steering Committee. There are more than 55,000
tissue specimens have been accumulated, more than 75,000 bloods and body fluid specimens have been collected. In September 2016, we were authorized by the Human Genetic Resources Management Office of the Ministry of Science and
Technology for approval of human genetic collection, trading, export and exit examination and approval. We also established the cancer molecular diagnostics including the biochips and the next-generation sequencing, and the corresponding
bioinformatics technology platforms. The platform acquired the pilot unit of the clinical application of high-throughput sequencing technology of the National Health and Family Planning Commission, while carried out predictions
of solid tumor-targeted drug susceptibility, and the risk prediction of inherited tumors such as breast cancer and thyroid cancer. The Center published a core journal, “Chinese Journal of Clinical Oncology”, selected as one of
TOP 50 projects of the Chinese Association of Science and Technology Quality Periodicals. It was also awarded the "Fourth Chinese Excellent Journal of Science and Technology" by the Ministry of Science and Technology. In 2018,
our English journal “Cancer Biology & Medicine’s impact factor was 4.607. It globally ranks 55th in 222 journals of oncology and 1st in 5 SCI journals of oncology in China.
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High-Level Talent Team Construction : the Center has fostering and importing 2 outstanding young talents of the National Natural Science Foundation of China, 4 Changjiang Scholars and Professors of the Ministry of Education, 2 talents of National Thousand
Talents program, 1 leading talent of National Million Plan. In additions, the expert recommended by the Center won the 2016 Chinese Government Friendship Award and were successfully elected as a foreign academician of the Chinese
Academy of Engineering in 2017.
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Scientific Research Construction: since the establishment of the center, there have been 285 scientific research projects at provincial and ministerial level, and the scientific research funding has reached 159.333 million yuan, including 4 National Key
R&D (Research and Development) Plans, 3 National Science and Technology Support Plans, 2 Major International Cooperation Projects of the National Natural Science Foundation, 1 Outstanding Youth Project, 1 Outstanding Youth Project,
and 1 Sino-Canadian Cooperation Project. There are more than 1,000 papers have been published in SCI journals, 28 papers in IF≥10 papers, and 25 technology awards provincial and ministerial level. We have lead/participated 73 multi-center
clinical studies and more than 70 projects in the formation of related guidelines.
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The Center will further implement the national innovation-driven development strategy, the “13th Five-year Plan on Technology and Innovation”, the “Plan of Health China 2030”, and the “13th Five-Year Plan for Health and Science & Technology Innovation”.
In accordance with the requirements of the “Five-Year Development Plan of the National Center for Clinical Research (2017-2021)”, which was jointly formulated by the Ministry of Science and Technology, the National Health and Family
Planning Commission, the Military Commission's Logistics Support Department and the General Administration of Food and Drug Administration, the Center would actively promote the center construction, improve the organizational structure
and network structure, optimize the allocation of resources, and improve the operational management system. Moreover, we will make the establishment of a high-level research platform for the oncology-transforming medicine, and
explore on the new modes and strategies for the tumor prevention. The diagnosis and treatment norms in the field of the common cancer could be improved and promoted, with rapidly advancing the innovative and popularization in the
field of cancer, to drive the overall level of the cancer prevention and treatment in China
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In 2012, the Ministry of Science and Technology, the Ministry of Health and the Ministry of General Health jointly commenced the construction of the National Clinical Research Center, which was executed in three stages, with the aim of building a total
of 32 centers. In June 2013 as the first stage, our center was established as one of the two National Clinical Research Centers in the field of cancer.
</p>
<p>
Academician Xishan Hao, the director of the Center,has established its organizational and management structure. The Center has formed a collaborative research network within two sub-centers, 20 regional centers and several grass-roots hospitals. We aim
to establish a high-level research platform for oncology-transforming medicine.
</p>
<p>
<span>Research Platform Construction:</span> the Center has established the specifications for the construction of a tissue sample bank for the collection and management of biological samples in accordance with international
standards and has formed an internationalized Steering Committee. It has accumulated more than 55,000 tissue specimens, and more than 75,000 blood and body fluid specimens. We also established cancer molecular diagnostics including
biochips and next-generation sequencing, and the corresponding bioinformatics technology platforms. The platform acquired pilot unit status for the clinical application of high-throughput sequencing technology from the National
Health and Family Planning Commission, which has enabled them to carry out predictions of solid tumor-targeted drug susceptibility, and risk prediction of inherited tumors such as breast cancer and thyroid cancer. The Center
has published a core journal: “Chinese Journal of Clinical Oncology”which has been selected as one of the TOP 50 projects of the Chinese Association of Science and Technology Quality Periodicals.In 2018, our English journal
“Cancer Biology & Medicine’s impact factor was 4.607, its global ranking was 55th in 222 journals of oncology and 1st in 5 SCI journals of oncology in China.
</p>
<p>
Academician Xishan Hao is the director of the Center,who established the organizational and management structure of the Center. The Center has been formed collaborative research network within two sub-centers, 20 regional centers and several grass-roots
hospitals.
</p>
<p>
<span>High-Level Talent Team Construction:</span> the Center has been developing its talent team by fostering and importing technical and professional personnel including: 2 outstanding young talents from the National Natural
Science Foundation of China, 4 Changjiang Scholars and Professors from the Ministry of Education, 2 talents from National Thousand Talents program, and 1 leading talent from the National Million Plan. In addition, the expert
recommended by the Center won the 2016 Chinese Government Friendship Award and was successfully elected as a foreign academician of the Chinese Academy of Engineering in 2017.
</p>
<p>
High-Level Talent Team Construction : the Center has fostering and importing 2 outstanding young talents of the National Natural Science Foundation of China, 4 Changjiang Scholars and Professors of the Ministry of Education, 2 talents of National Thousand
Talents program, 1 leading talent of National Million Plan. In additions, the expert recommended by the Center won the 2016 Chinese Government Friendship Award and were successfully elected as a foreign academician of the Chinese
Academy of Engineering in 2017.
</p>
<p>
<span>Scientific Research Construction:</span> since the establishment of the center, it has attracted 285 scientific research projects at provincial and ministerial level, and the scientific research funding has reached 159.333
million yuan, including 4 National Key R&D (Research and Development) Plans, 3 National Science and Technology Support Plans, 2 Major International Cooperation Projects from the National Natural Science Foundation, 1 Outstanding
Youth Project, and 1 Sino-Canadian Cooperation Project. More than 1,000 papers have been published in SCI journals, 28 papers in “IF≥10 papers”, and we have won 25 technology awards at provincial and ministerial level. We have
led/participated in 73 multi-center clinical studies and undertaken more than 70 projects to develop the related guidelines.
</p>
<p>
The Center will further implement the National Innovation-driven Development Strategy, the “13th Five-year Plan for Technology and Innovation”, the “Plan of Health China 2030”, and the “13th Five-Year Plan for Health and Science & Technology Innovation”.
In accordance with the requirements of the “Five-Year Development Plan of the National Center for Clinical Research (2017-2021)”, which was jointly formulated by the Ministry of Science and Technology, the National Health and
Family Planning Commission, the Military Commission's Logistics Support Department and the General Administration of Food and Drug Administration, the Center will actively promote its development, improve its organizational
and network structure, optimize its allocation of resources, and improve its operational management system.
</p>
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