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<h3>Public Laboratory</h3>
<p>
<h3>Introduction</h3> <br>
In line with Tianjin medical university cancer hospital’s overall teaching and research
development objectives, to strengthen and enhance the fundamental and applied research, to
cultivate top-notch creative talent, and to ensure that the available research resources
will be efficiently used, our hospital organized and set up in 2009Public Experimentation
Center, located on thesixth floor of Building C.
After several years of investment and construction, and relying on the strengths of our
faculty and technology, our centerhave evolved into a comprehensive research center dotted
with logical organization, high efficiency, opening-up, and advanced technology.
The center consists of four technical service-orientedplatforms, i.e., the core facility
and
technical service Platform, the Clinical Laboratory, the SPF Animal Laboratory
andtheBioinformatics Platform.The center covers an area of about 2000 m2, the value is
worth
over 50 million RMB.
Now, the Public Laboratory is not only an important experimental base for conducting
scientific research and translational medicine research, but also a supporting platform for
cultivating top-notch creative medical talent.
</p>
<h3> Services</h3>
<img src="../images/ins_2.png" alt="" srcset="">
<p>
1. The core facility and technical service platform is funded by Tianjin medical university
cancer institute & hospital. The establishment of this platform will provide centralized and
expertise support to our colleagues requiring these advanced technology platforms in their
research studies. It will enhance effective usage of resources and maximize the use of
expensive instruments required for these advanced technology platforms. The platform is
equipped with Laser Scanning Confocal Microscope, Flow Cytometer, Upright Fluorescent
Microscope, Inverted Fluorescent Microscope, Real-Time PCR apparatus, Ultra-Centrifuge and
so on.The appointments software (LIMS) has been used deeply along with the servicesto
enhance service abilityand to improve the service efficiency.
</p>
<img src="../images/ins_3.png" alt="" srcset="">
<p>
2. The clinical laboratory is a research platform for translational medicine. The objective
of the clinical laboratory is to provide multidisciplinary scientists from different faculty
of TJMUCH a synergistic platform which efficiently and effectively translate basic
scientific findings into knowledge that benefits patients, which is often described as an
effort to carry scientific knowledge ‘from bench to bedside’. At present, we have 17
different research groups at the clinical laboratory, all of which engage in cutting-edge
research. The research group (under the management of principal investigator) is a group of
researchers or students from the same faculty working together on a particular issue or
topic. In this way we hope to stretch boundaries, challenge traditional ways of thinking,
and innovate towards finding new solutions to problems. Now, the clinical laboratory is home
to world-class research facilities, a specialist clinical trials unit and a suite of
molecular biology laboratories.
</p>
<img src="../images/ins_4.png" alt="" srcset="">
<p>
3. The SPF Animal Laboratory, with a total floor area of about 500 m2, is a comprehensive
service entity involved in research of Laboratory Animal Science, providing technical
support and services for animal research. It includes SPF (Specific-pathogen-free) barrier
environment, conventional environment and functional auxiliary environment. Relevant
environmental facilities obtained the experimental animal use license (SYXK (Tianjin)
2012-0005) issued by Tianjin Municipal Science and Technology Commission in 2012, and
successfully replaced the new experimental animal use license (SYXK (Tianjin) 2017-0005) in
2017, providing a strong guarantee for the scientific research of our discipline.Our staff
provides daily animal care for the 15,000 animals used in research and teaching
hospital-wide. Our goal remains to support the needs of our biomedical research community by
providing an optimal environment for their animals and research.
</p>
<img src="../images/ins_5.png" alt="" srcset="">
<p>
4. Our research focuses on characterizing mutational landscape of human gastrointestinal
cancer, elucidating the association between mutational footprints and environmental factors,
identifying biomarkers with translational significance in immunotherapy and early cancer
diagnosis, and interpreting medical imaging data using deep learning algorithms. Through
bioinformatics analyses, we identified new driver genes underlying the development of
gastrointestinal cancer, and shed new lights on genetic markers that are potentially
clinically actionable. By applying deep learning algorithm to analyze large-scale
sonographic imaging data, we developed a deep learning model that could augment
radiologists’ ability in thyroid cancer diagnosis. We have published more than 20
peer-reviewed articles in international journals, including Lancet Oncology, JAMA Oncology,
and Annals of Oncology etc.
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